Maren Bell Jones said:
For humans at least, it all depends on how it is prepared. The pesticides and the heavy metals accumulate in the fat of the animal (which is how most things are bioaccumulated) and so the reason bears eat a lot of salmon and haven't been effected by endocrine disruptors as much is because they apparently strip off the skin and a lot of the fat.
I watched a documentary a couple years ago on bears and the salmon run. In this it showed the bears stripping off the skin, but it was so they could eat the skin/fat only. Get the most "bang for the buck" in calories vs amount ate. Since fish are so plentiful during the run, they were leaving behind most of the meat and eating only the "best" parts (skin, head and roe in females). In leaner times they eat the entire fish.
I grew up on the Southern Oregon coast, and we ate salmon on a regular basis. Pan fried, poached, baked, grilled, you name it. Yum

Occasionally you heard of a dog (ours or a neighbors) who got salmon poisoning from eating fish along the riverbank, but they usually got over it with a round of antibiotics, and I was always told once they had it, they wouldn't get it again. Not sure if that's true or not.
I feed my dogs salmon on a semi-regular basis. I find it labeled for chowder in the grocery store, usually it's whats left after they have cut the fish into steaks, the parts that they couldn't get large "pretty" steaks from. Most of my dogs love it, a couple aren't interested. But none have had any problems from eating it.